There is plenty of good action on the card this week, but for me, the spotlight game is in Indianapolis, where two of the most exciting rookie quarterbacks from last season meet when the undefeated Seattle Seahawks with Russell Wilson take on Andrew Luck and the Colts.

Seattle (4-0) is laying -3 points to the Colts (3-1).

Luck, who was selected by the Colts first overall in the 2012 NFL Draft, is 14-6 in his career, a record that matches John Elway for the best 20-game start by a quarterback drafted No. 1 overall. Today he puts his talent and his team’s undefeated mark up against Richard Sherman, arguably the best cornerback in the NFL. The Colts have won and covered six straight as a home underdog, and roll into this one on home winning streaks of 10-2 straight-up and 9-3 at the window.

Seattle, meanwhile, is on a perfect 5-0 ATS streak with a suitcase in hand, and Wilson is a major reason for the success. The second-year pro, who was selected by the Seahawks with the 12th pick in the third round (75th overall), comes into this one after leading Seattle from two scores down in the fourth quarter in last week’s 23-20 overtime win in Houston.

Seattle has won nine straight regular-season games and 11 of last 12, while the Colts are 8-2 at home since coach Chuck Pagano took over last season.

Other games of interest and their numbers to note include:

New England (-1) at Cincinnati – The Patriots have won 13 of their last 14 games in the regular season, including six straight while ordering room service. … The Patriots have won their last four games against the Bengals and seven of the last eight. … Meanwhile, the Bengals have won five of their last six at home both SU and ATS.

Detroit at Green Bay (-7′) – The Packers’ 21 straight regular-season wins at home against the Lions, including games played in Milwaukee, is the longest in NFL history. … Including a playoff win, the streak is actually 22. … The Packers have won nine straight at home against all NFC North opponents. … Green Bay is on winning runs of 6-1 SU and 7-0 ATS after bye week under coach Mike McCarthy. … The Lions are mired in an ATS road losing streak of 1-6 when catching points.

New Orleans (-1′) at Chicago – The Saints remain one of two unbeaten NFC teams, along with Seattle. … The Saints last won at Soldier Field in 2000, and are 0-3 there under coach Sean Payton, including the 2006 NFC championship game. … The last 5 meetings at Soldier Field have gone over the posted total. Chicago is mired in an ugly 1-7 ATS slide at home.

Denver (-9) at Dallas – The Broncos have won four straight and have covered 7 of 8 against the Cowboys. … The Broncos have won 15 straight regular-season games by seven or more points – the second-longest streak behind the 1941-42 Bears. Since running back DeMarco Murray – a graduate of Las Vegas powerhouse Bishop Gorman High School – became the primary running back for the Cowboys, they’re 11-0 when he carries the rock at least 18 times; they’re 1-10 when he doesn’t. … The Cowboys have the best record in interconference games since 1970, however, they’ve dropped three straight to the AFC West, including two this year to the Chiefs and Chargers. … The Broncos are on winning runs of 7-1 SU and 6-2 ATS as a road favorite and 8-1 against NFC East teams.

Houston at San Francisco (-4′) – The home team has won the last two meetings, both by three points. … The Texans are the only NFL team with a top-five offense and defense. … The Texans are mired in a 1-5 ATS slide on the road. … The 49ers have lost 7 of 9 straight-up against teams out of the AFC South.

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